Right click on the Notezilla icon in the taskbar (next to the clock) and choose 'Preferences' from the menu to open the Preferences window. Then click on the 'Hotkeys' tab.
A hotkey is a system-wide unique key combination assigned to an action. Make sure you specify a key combination that is not used by any other program.
To set a hotkey, select an action from the list, specify the key combination in the text box below the list, and choose the 'Apply' button.
To remove a hotkey, select an action from the list, press backspace key in the text box below the list so that the text box shows 'None' and choose Remove button.